Topic 2: Antigen recognition

Kinetic Proofreading:

Readings for the next session on the 12.11.21:

• Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity, J. Hopfield, PNAS, 1974.
• Kinetic proofreading in T-cell receptor signal transduction, T. McKeithan, PNAS, 1995
• Discrimination of membrane antigen affinity by B cells requires dominance of kinetic proofreading over serial engagement, P Tsourkas, et.al., Nature, 2012

Readings for the next session on the 19.11.21:

• The kinetics of peptide reactions with class II major histocompatibility complex membrane proteins, S. N. Witt and H. M. McConnell, Acc. Chem. Res., 1993.
• Thermodynamic and Kinetic Analysis of a Peptide−Class I MHC Interaction Highlights the Noncovalent Nature and Conformational Dynamics of the Class I Heterotrimer, A-K. Binz, et.al., Biochemistry, 2003

Readings for the next session on the 26.11.21:

• Theories and quantification of thymic selection, A. J. Yates, frontiers in Immunology, 2014.
• Other recommended readings (Not mandatory):
  • Positive and Negative Selection of T Cells, T. K. Starr, et.al., Annual Review of Immunology, 2003
  • Antigen Processing - Methods and Protocols, P.van Endert, Springer Protocols, 2019, Chapter 23

Readings for the next session on the 07.12.21:

• Quantitative immunology for physicists, G. Altan-Bonnet, et.al. (2020) Sections: 2.4.1
• Theories and quantification of thymic selection, A. J. Yates, frontiers in Immunology, 2014.

Readings for the next sessions on the 14.12.21 and 20.12.21:

• A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy, M. Luksza, et.al, 2017.
• Effects of thymic selection on T cell recognition of foreign and tumor antigenic peptides, J. T. George, et.al, 2017.